Interactions between drug particulates are crucial in determining drug dispersion and deaggregation, and ultimately delivery efficiency. This book combines principles and factors in pharmaceutical powder technology, critically reviews some of the studies carried out in dry powder formulation development, and proposes possible strategies for improving their efficiency. The majority of these principles are applicable to other pharmaceutical solid dosage forms (e.g. tablets and capsules).

This interface is being recognized by business organizations as a key priority for management, and both practitioners and academics alike have placed a greater emphasis on the need to view the supply chain as a whole as the vehicle by which competitive advantage is achieved. As well as drawing upon current research and the experience of firms worldwide, Marketing Logistics uses numerous 'mini-cases' and vignettes to illustrate the key messages in each chapter and bring the theory to life. This book is an invaluable resource for managers who seek to understand more about the way in which the supply chain should be managed to improve their organization's competitive position, as well as students undertaking degree-level courses in marketing, logistics and supply chain management.

Relationship Marketing: Creating Stakeholder Value extends the analysis of the change in the marketing rationale from a crude concern for increased market share to a strategy aimed at creating long-term profitable relationships with targeted customers. Offering a cutting edge vision of relationship marketing, Relationship Marketing: Creating Stakeholder Value is a seminal text for all students and managers in the field. With new up-to-date case materials and examples of best practice, the book covers all the stakeholder markets - employees, suppliers, influencers, customers and consumers - for which the relationship approach is critical. It also provides crucial advice on how to develop, integrate and implement the various strands of a successful relationship strategy.

Relationship Marketing: Creating Stakeholder Value extends the analysis of the change in the marketing rationale from a crude concern for increased market share to a strategy aimed at creating long-term profitable relationships with targeted customers.Offering a cutting edge vision of relationship marketing, Relationship Marketing: Creating Stakeholder Value is a seminal text for all students and managers in the field. With new up-to-date case materials and examples of best practice, the book covers all the stakeholder markets - employees, suppliers, influencers, customers and consumers - for which the relationship approach is critical. It also provides crucial advice on how to develop, integrate and implement the various strands of a successful relationship strategy.

Interactions between drug particulates are crucial in determining drug dispersion and deaggregation, and ultimately delivery efficiency. This book combines principles and factors in pharmaceutical powder technology, critically reviews some of the studies carried out in dry powder formulation development, and proposes possible strategies for improving their efficiency. The majority of these principles are applicable to other pharmaceutical solid dosage forms (e.g. tablets and capsules.).

eBook available with sample pages: 0203209591

Delivering successful procurement programs has helped businesses like IKEA, Tesla and Nike maximize the potential of their resources and gain the competitive advantage. Learn how to develop similar strategies, that meet the needs of the business, customers and suppliers, and lead their implementation using insights from the experts in procurement strategy. Leading Procurement Strategy provides readers with a complete overview of the skills, knowledge and tools needed to implement a successful procurement strategy. The expert author team of Carlos Mena, Remko van Hoek, and Martin Christopher present practical advice and guidance underpinned by academic theory and supported by an extensive range of real-world case studies including IBM, IKEA, John Deere, NASA, Nike and Tesla. Readers are shown how to develop, deliver and sustain procurement performance with clear and accessible guidance. The third edition offers the latest insights into the future of procurement and digitalization, updates on green and socially responsible procurement and a revised structure. The key issues affecting the procurement function are covered and tips for developing the best practices in teams are found throughout.

Delivering successful procurement programs has helped businesses like IKEA, Tesla and Nike maximize the potential of their resources and gain the competitive advantage. Learn how to develop similar strategies, that meet the needs of the business, customers and suppliers, and lead their implementation using insights from the experts in procurement strategy. Leading Procurement Strategy provides readers with a complete overview of the skills, knowledge and tools needed to implement a successful procurement strategy. The expert author team of Carlos Mena, Remko van Hoek, and Martin Christopher present practical advice and guidance underpinned by academic theory and supported by an extensive range of real-world case studies including IBM, IKEA, John Deere, NASA, Nike and Tesla. Readers are shown how to develop, deliver and sustain procurement performance with clear and accessible guidance. The third edition offers the latest insights into the future of procurement and digitalization, updates on green and socially responsible procurement and a revised structure. The key issues affecting the procurement function are covered and tips for developing the best practices in teams are found throughout.

Latin America is a well recognized and growing market, but its poor infrastructure, explosive urbanization, expensive and inefficient logistics, and multiple social problems continue to pose major problems to logistics professionals and academics. The uniqueness and complexity of these issues have long daunted scholars, and there remains an important gap in the literature around Latin American supply chain management and logistics (SCM&L). Supply Chain Management and Logistics in Latin America brings together leading scholars across Brazil, Colombia, Cuba, Ecuador, Peru, Panama, and the USA in order to address this gap. The chapters collected here, all of which are drawn from selected papers presented at the 2016 MIT SCALE Latin American Conference on Logistics and Supply Chain Management, offer perspectives from five different countries-Brazil, Colombia, Ecuador, Panama, and Peru-and provide insights into cases and new methods written by people who have faced the challenges they discuss. The authors cover a broad range of subjects: in addition to general contributions to qualitative and quantitative methods in supply chain management and coverage of cases of global importance such as the Panama Canal expansion, they offer insights into regionally specific problems around freight corridors in Colombia, reverse logistics and recycling in Colombia, supply risk management in Colombia, and socially oriented logistics in low-income communities in Peru. Since Latin America is one of the most urbanized regions in the world, with about eighty percent of the population living in cities, questions around urban logistics also receive heavy coverage, with four chapters discussing issues unique to very high-density cities and megacities such as Sao Paulo, Rio de Janeiro, Bogota, and Quito. For its explorations of important themes, methods, and local topics within a crucial and ever-expanding market, Supply Chain Management and Logistics in Latin America is a valuable resource for educators, researchers, and practitioners.

Most successful companies have operations management at their heart. It enables strategy and should be part of boardroom discussions. However, Cranfield research has shown that business strategy barely recognises the world of operations management. Recognising that operations management needs to be more strategic, Business Operations Models is a revolutionary new title that looks at the interrelationship of operations management and strategy. In Business Operations Models, Martin Christopher and Alan Braithwaite identify the characteristics of market-leading businesses that have transformed their markets and delivered super performance for their stakeholders. It points to the theory gap between strategic thinking and operations and how many high-performing businesses arrive at their new operating models as much by chance as judgement. Unpacking those observations leads to some clearly defined features of winning competitors, including eliminating waste, leveraging technology, and utilising transformative business models. Business Operations Models offers a framework for achieving super performance and understanding when and how a company may be able to leverage its capabilities to outperform. The book provides detailed international case studies that illustrate how the principles work in practice, including Apple, Dell, Amazon, John Lewis, Southwest airlines, Aldi, Toyota and many others.

Supply chains and the logistics activities that drive them are critical to business success. Logistics and Supply Chain Management has the most up-to-date practical tools to manage the people and processes that allow businesses to gain and maintain competitive advantage through their supply chains. You’ll discover how effective development and management of supply chain networks will help businesses cut costs and enhance customer value. The sixth edition of this bestselling book has been completely updated: as well as additional examples and case studies throughout, there are two new chapters covering: The Digital Supply Chain Sourcing and supply management  

Everything we know about Alexander comes from ancient sources, which agree unanimously that he was extraordinary and greater than everyday mortals. From his birth into a hypercompetitive world of royal women through his training under the eyes and fists of stern soldiers and the piercing intellect of Aristotle; through friendships, rivalries, conquests and negotiations; through acts of generosity and acts of murder, this book explains who Alexander was, what motivated him, where he succeeded (in his own eyes) and where he failed, and how he believed that he earned a new 'mixed' nature combining the human and the divine. This book explains what made Alexander 'Great' according to the people and expectations of his time and place and rejects modern judgments asserted on the basis of an implicit moral superiority to antiquity.

Everything we know about Alexander comes from ancient sources, which agree unanimously that he was extraordinary and greater than everyday mortals. From his birth into a hypercompetitive world of royal women through his training under the eyes and fists of stern soldiers and the piercing intellect of Aristotle; through friendships, rivalries, conquests and negotiations; through acts of generosity and acts of murder, this book explains who Alexander was, what motivated him, where he succeeded (in his own eyes) and where he failed, and how he believed that he earned a new 'mixed' nature combining the human and the divine. This book explains what made Alexander 'Great' according to the people and expectations of his time and place and rejects modern judgments asserted on the basis of an implicit moral superiority to antiquity.

This interface is being recognized by business organizations as a key priority for management, and both practitioners and academics alike have placed a greater emphasis on the need to view the supply chain as a whole as the vehicle by which competitive advantage is achieved. As well as drawing upon current research and the experience of firms worldwide, Marketing Logistics uses numerous 'mini-cases' and vignettes to illustrate the key messages in each chapter and bring the theory to life.This book is an invaluable resource for managers who seek to understand more about the way in which the supply chain should be managed to improve their organization's competitive position, as well as students undertaking degree-level courses in marketing, logistics and supply chain management.

Most successful companies have operations management at their heart. It enables strategy and should be part of boardroom discussions. However, Cranfield research has shown that business strategy barely recognises the world of operations management. Recognising that operations management needs to be more strategic, Business Operations Models is a revolutionary new title that looks at the interrelationship of operations management and strategy. In Business Operations Models, Martin Christopher and Alan Braithwaite identify the characteristics of market-leading businesses that have transformed their markets and delivered super performance for their stakeholders. It points to the theory gap between strategic thinking and operations and how many high-performing businesses arrive at their new operating models as much by chance as judgement. Unpacking those observations leads to some clearly defined features of winning competitors, including eliminating waste, leveraging technology, and utilising transformative business models. Business Operations Models offers a framework for achieving super performance and understanding when and how a company may be able to leverage its capabilities to outperform. The book provides detailed international case studies that illustrate how the principles work in practice, including Apple, Dell, Amazon, John Lewis, Southwest Airlines, Aldi, Toyota and many others.

From 2007 to 2012, almost five percent of American adults-about ten million people-lost their homes because they could not make mortgage payments. The scale of this home mortgage crisis is unprecedented-and it's not over. Foreclosures still displace more American homeowners every year than at any time before the twenty-first century. The dispossession and forced displacement of American families affects their health, educational success, and access to jobs. It continues to block any real recovery in the hardest-hit communities. While we now know a lot about how this crisis affected the global economy, we still know very little about how it affected the people who lost their homes. Foreclosed America offers the first representative portrait of those people-who they are, how and where they live after losing their homes, and what they have to say about their finances, their neighborhoods, and American politics. It is a sobering picture of Americans down on their luck, and of a crisis that is testing American democracy.

John and Abigail Adams' reflections on an emerging nation as they move into the new President's House in Washington, D.C., are a highlight of the nearly 280 letters written over seventeen months printed in volume 14 of Adams Family Correspondence. The volume opens with the Adamses' public and private expressions on the death of George Washington and concludes with John's defeat in the contentious presidential election of 1800. Electoral College maneuvering, charges of sedition, and state-by-state strategizing are debated by the Adamses and their correspondents as the election advances toward deadlock and finally victory for Thomas Jefferson in the House of Representatives. John's retirement from public life had some sweet mixed with the bitter. The U.S. mission to France resulted in the Convention of 1800 that ended the Quasi-War and the so-called midnight appointments at the close of his presidency ushered in the transformative U.S. Supreme Court era of John Marshall, a coda anticipated in Abigail's request to John in the final days of his administration-"I want to see the list of judges." The domestic life of the Adamses was equally dynamic. Abigail and John endured the crushing loss of their son Charles, whose struggle with alcohol ended in repudiation and death in New York. Son Thomas Boylston and daughter Nabby spent the period in relative stability, while John Quincy chronicled a tour of Silesia in letters home from Europe. At the volume's close, the correspondence between John and Abigail comes to an end. As they retired to Quincy, their rich observations on the formation of the American republic would continue in letters to others if not to each other.

John and Abigail Adams remained fully engaged in American political life after they left Washington, DC, for retirement in Quincy. A highlight of Volume 15 of Adams Family Correspondence is a series of letters between Abigail Adams and Thomas Jefferson that debated fundamental questions of the nation’s tumultuous early years. A new generation rose in prominence in the period covered in the volume, with John Quincy Adams returning from abroad to take a seat in the United States Senate just in time to break with the Federalists and support the Louisiana Purchase. The family commented on other events of the era—Jefferson’s dismantling of John Adams’s judicial reforms, the mobilization of the US Navy for the Barbary wars, the growing bane of British impressment, and the duel that killed Alexander Hamilton. Equally compelling family stories emerge in the volume’s 251 letters. The failure of a British banking firm proved calamitous to the family’s finances, compelling John Quincy to quietly finance his parents’ retirement. Thomas Boylston Adams, acting as an occasional editor of the Port Folio, carved out his public persona as a man of letters. Louisa Catherine Adams wrote of motherhood and adjusting to a new country of residence while providing a spirited perspective on Washington society. As always, the heart of Adams Family Correspondence is Abigail Adams, who survived a near-fatal fall to continue providing letters of insight and wit that once again show why the correspondence of the Adams family is a national treasure.

A major contribution to the history of Parliament, to medieval English history, and to the study of the English constitution. ENGLISH HISTORICAL REVIEW The rolls of parliament were the official records of the meetings of the English parliament from the reign of Edward I (1272-1307) until the reign of Henry VII (1485-1509), after which they were superseded by the journals of thelords, and, somewhat later, the commons. Chris Given-Wilson is Professor of Late Medieval History, University of St Andrews

Phytophagie, Pr dation, Konkurrenz und Mutualismus bestimmen die vielf ltigen Wechselbeziehungen zwischen Pflanzen, Tieren und Mikroorganismen in ihren jeweiligen Lebensr umen. In dieser ersten deutschsprachigen Einf hrung zur kologie der Bioz nosen betrachten die Autoren die Wirkungen dieser Interaktionen: auf die Zahl der Arten und Individuen und auf die Regulationsprozesse in Bioz nosen. Grundlagen und j ngste Forschungsergebnisse werden anhand zahlreicher Fallbeispiele und detailgenauer Zeichnungen und Grafiken anschaulich vermittelt.

Die Mechanik von Industrierobotern wird - basierend auf Erfahrung und Intuition - derzeit weitgehend manuell ausgelegt. In der vorliegenden Veroeffentlichung werden die wichtigsten Schritte zur Konzeption der Mechanik von Robotern aufgezeigt und hierfur rechnergestutzte Verfahren angewendet, angepasst oder neu konzipiert. Ein wichtiges Ziel ist eine gute Annaherung des analytischen Modells an die reale Roboterstruktur. Die wesentlichen Erkenntnisse dieser Arbeiten werden in funf Grundfragen zusammengefasst. Mit deren Beantwortung wird ein eindeutiger Loesungsweg zur Konzeption der Mechanik unter Verwendung der entwickelten rechnergestutzten Verfahren vorgeschlagen. Unter Berucksichtigung der aufgezeigten Grenzen lassen sich mit Hilfe des erarbeiteten Instrumentariums kostengunstigere oder leistungsfahigere mechanische Geratekonzepte realisieren.